The Regenerative and Muscle Biology (RMB) lab is a multidisciplinary and interactive group of dedicated scientists keen on translating basic research findings into therapeutically applicable treatments. We work at the intersection of molecular and cellular biology, cell-based therapies, tissue engineering, and cellular agriculture. As such, our lab concentrates on a wide range of research objectives, employing a battery of cutting-edge methods in biology to address experimental goals spanning various research fields.

As our core research model, we focus on skeletal muscle, a soft tissue that comprises around 40% of normal human body mass. This tissue is composed of multinucleated muscle fibers that contract to generate locomotion and mononucleated cells, most notably stem cells known as satellite cells, that can regenerate the tissue upon injury or disease. Satellite cell regenerative propensity is derailed in many diseases and effective curative treatments are currently lacking. One of the primary longterm goals of our laboratory is directed towards developing novel therapeutic approaches to treat degenerative loss of muscle mass. To this end, we utilize direct reprogramming approaches to convert somatic cells into regenerative-competent and expandable myogenic stem cells suitable for potential therapies.