Main content

Welcome to the Laboratory of Regenerative and Movement Biology

The Regenerative and Movement Biology (RMB) lab is a multidisciplinary and interactive group of dedicated scientists keen on translating basic research findings into therapeutically applicable treatments. We work at the intersection of molecular and cellular biology, cell-based and gene therapies, tissue engineering, and cellular agriculture. As such, the lab concentrates on a wide range of research objectives, employing a battery of cutting-edge methods in biology to address experimental goals spanning various research domains and fields.

As our main research model, we focus on skeletal muscle, a soft tissue that comprises around 40% of normal human body mass. This tissue is composed of multinucleated muscle fibers that contract to generate locomotion and mononucleated cells, most notably stem cells known as satellite cells, that can regenerate the tissue upon injury or disease. Satellite cell regenerative propensity is derailed in multiple diseases and effective curative treatments are lacking. The primary long-term goal of our laboratory is directed towards developing novel cell-based and gene therapy approaches to treat degenerative loss of muscle mass. To this end, we utilize direct reprogramming to convert somatic cells into regenerative-competent and expandable myogenic stem and progenitor cells suitable for potential therapies. Separately, given our expertise in myogenic cell line cultivation, our research group further explores means to reduce costs of cultivated meat production via generation of unique muscle stem cell lines from domesticated animals, which can be used as a future source for sustainable food.

 

 

News & Events

Oral presentation by Giada Bacchin at the FSRMM meeting

Inseon Kim awarded the title PhD

New lab publication

New lab publication

"Poster Teaser" by Adhideb Ghosh at the 2023 ISSCR meeting

Awards

Best Oral Presentation Award to Christine Trautmann

ETH Medal to Pjeter Gjonlleshaj for best MSc thesis

Best MSc thesis award to Ajda Lenardic

Travel and Abstract Merit awards to Adhideb Ghosh

Two travel awards to Xhem Qabrati

JavaScript has been disabled in your browser